| The notion of hypothyroxinemia of the mother was | | | | established a comparable association among first |
| established as as the amount in the blood of thyroxine, | | | | trimester thyroxine and the early neurodevelopment of |
| under the standard value for women in the identical | | | | babies born from treated mothers with hypothyroidism. |
| trimester of pregnancy, regardless if hypothyroidism | | | | These investigations did not discover important |
| was clinically apparent or not. Pertinent information is | | | | associations when the neurodevelopmental result was |
| available from research performed in regions without | | | | linked to maternal TSH, or to thyroxine later in |
| severe iodine deficiency, which have suggested a | | | | pregnancy. The result that thyroxine amount after |
| significant function of maternal thyroxine in the | | | | midgestation are not interconnected with the |
| conclusion of the pregnancy and in the | | | | developmental effect does not indicate that after |
| neuropsychological development of the offspring, | | | | midgestation the defensive outcome of maternal |
| offering growing proof that is the decisive cause in | | | | thyroxine has been vanished, or that the fetal brain no |
| maternal hypothyroxinemia early in development. | | | | longer have need of thyroid hormone. |
| There are a lot of information concerning the | | | | Punctual postnatal management of children without |
| augmented amount of failed or difficult pregnancies in | | | | thyroid gland function avoids the cruel mental |
| maternal hypothyroxinemia including congenital | | | | retardation that was connected with this disease when |
| malformations, complications at delivery, perinatal | | | | start of management was postponed. This very |
| deaths, births before term, spontaneous abortions, etc | | | | optimistic result has been quoted as argument that the |
| and their association to first trimester low thyroxine, but | | | | human fetal brain does not require thyroid hormone for |
| not to thyroxine near term; treatment near the | | | | normal development before birth. It has been argued |
| beginning to avoid such complications has been | | | | an optional reason about that the fetal encephalon is |
| proposed. Such original investigations not just illustrates | | | | commonly protected by the regular thyroid condition of |
| the level of interest to the reduced cerebral maturity of | | | | their mothers. In other words, when thyroid hormone |
| the children of hypothyroxinemic women but also | | | | values of the mother are not regular during pregnancy |
| described that this negative outcome was blocked by | | | | and thyroid function in the fetus is injured as well, |
| sufficient and early improvement of the maternal | | | | neurological break and mental retardation of the infant |
| hypothyroxinemia with thyroid supplementation. | | | | would be as brutal as in neurological cretinism, even |
| Some studies have confirmed data contrasting | | | | though instantaneous postnatal management of the |
| indicators during prenatal growth, calculated at different | | | | newborn with thyroxine. |
| ages, with maternal thyroxine. Such studies have | | | | |